By Arthur M. Silverstein

ISBN-10: 012643770X

ISBN-13: 9780126437706

This can be a professional-level highbrow historical past of the advance of immunology from approximately 1720 to approximately 1970. starting with the paintings and insights of the early immunologists within the 18th century, Silverstein strains the improvement of the main principles that have shaped immunology right down to the maturation of the self-discipline within the decade following the second one global warfare. Emphasis is put on the philosophic and sociologic weather of the clinical milieu within which immunology has built, offering a heritage to the huge tradition of the self-discipline.

Key Features
* A professional-level highbrow heritage of the advance of immunology from approximately 1720 to 1970, with emphasis put on the social weather of the medical milieu within which glossy immunology evolved
* Written by way of an writer rather well recognized either as a historian of clinical technology and for his vast learn contributions to the immunopathology of the eye
* the one whole background of immunology to be had

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Voltaire's candidate was Lady Mary Wortley Montagu. A contemporary account published by a German visitor maintained that it was Maitland who appealed to the princess for permission to experiment further with the procedure, 1 9 while Sloane's own "Account of Inoculation," written some 15 years after the event (and, unaccountably, not published until 1756) held that Princess Caroline, "to secure her other children, and for the common good, begged the lives of six condemned criminals . . " 20 But Sloane's retrospective account contains other inaccuracies, and perhaps it does not do justice to his own role in the affair, as one of the most powerful promotors of the new scientific movement in England.

Med. Wochenschr. 16, 1145 (1890). For an earlier version, see P. Grawitz, Wirchow's Arch. 84, 87 (1881). 2 The Royal Experiment on Immunity, 1 7 2 1 - 1 7 2 2 B Y T H E middle of the seventeenth century, smallpox (along with typhus) had replaced the plague as the leading infectious disease causing death in the adult population of Europe. 1 Epidemics of smallpox appeared with increasing frequency 2 and were all the more noticed because, unlike many other contemporary diseases, they afflicted the rich and powerful as well as the poor.

The specificity of this immunity was explained by assuming that each species of pathogen produced substances peculiar to its own metabolism and to whose inhibitory effect they alone were sensitive. This theory was taken up and championed before the French Academy of Sciences by Chauveau, Director of the Veterinary School at Lyon. 48 In studies of anthrax infection of Algerian sheep, Chauveau observed that the offspring of ewes infected during pregnancy, and especially shortly before parturition, showed an increased resistance to anthrax infection.

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A History of Immunology by Arthur M. Silverstein


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