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Extra resources for Annual Review of Immunology Volume 13 1995
Natl. Acad. Sci. USA78:384447 67. Good MF, Pyke KW,Nossal GJV. 1983. Functional clonal deletion of cytotoxic Tlymphocyteprecursors in chimeric thymus producedin vitro from embryonicanlagen. Proc. Natl. Acad. Sci. USA80:3045-49 68. Nossal GJV, Pike BL. 1973. Studies on the differentiation of B lymphocytesin the mouse. Immunology 25:33-45 69. OsmondDG, Nossat GJV. 1974. Differentiation of lymphocytesin mousebone marrow, II. Kinetics of maturation and renewal of antiglobulin-binding cells studied by double labeling.
These factors, plus the polyclonality and multispecificity of the CTLresponse, mitigate against the emergenceof viral escape mutantsduring acute viral hepatitis. Until receiitly, the only information about the CTLresponse during chronic hepatitis described studies in which PBMC were reported to accelerate the detachmentof biopsy-derivedautologoushepatocytes from tissue culture dishes under conditions that could be blocked by anti-nucleocapsid antibodies (9). These studies are often cited as evidence that HBcAg-specificCTLplay a dominantrole in the pathogenesis of chronic hepatitis B.
Rev. Immunol. 11:501-38 60. Nossal GJV, Ada GL, Austin CM. 1965. X. Induction of immunological tolerance to Salmonella adelaide flagellin. J. 95:665-73 61. Mitchison NA. 1964. Induction ofimmunological paralysis in two zones of dosage. Proc. R. Soc. (B) 161:275-92 62. Shellam GR, Nossal GJV. 1968. Mecha- Annual Reviews Annu. Rev. Immunol. 13:1-28. org by HINARI on 08/31/07. For personal use only. ANTIBODY FORMATION OR TOLERANCE? nism of induction of immunologicaltolerance, IV. Theeffects of ultra-low doses of flagellin.
Annual Review of Immunology Volume 13 1995 by Annual Reviews